Omega-6 fatty acids are well-supplied in the diet by meat and vegetable oils. However, not all omega-6 fatty acids are of equal value. Arachidonic acid (AA) tends to be unhealthy because it is the precursor of inflammatory eicosanoids — such as prostaglandin E2 (PGE2), thromboxane A2, and leukotriene B4 — which promote inflammation. In contrast, gamma-linolenic acid (GLA), found in evening primrose oil, borage oil, and black currant oil, is an important fatty acid that plays a beneficial role in healthy prostaglandin (PGE1) formation and pro-inflammatory mediator reduction.20
Health-conscious people have been swallowing a lot of borage oil supplements to obtain GLA (gamma linolenic acid), the parent of the biologically active DGLA (dihomogamma linolenic acid).
Life Extension adds 10 mg of sesame lignans to each softgel of Mega GLA borage oil. Sesame lignans not only increase beneficial DGLA but they also prevent the conversion of GLA into the proinflammatory mediator arachidonic acid.56 Blocking this pathway decreases the formation of destructive proinflammatory agents prostaglandin E2 and leukotriene B4.57
Numerous studies document GLA’s multiple health effects. Enhancing this supplement with sesame lignans enables GLA to work much better in the body, allowing many more people with inflammatory-related problems to benefit from supplemental GLA.
|Serving Size 1 softgel|
|Servings Per Container 60|
|Amount Per Serving|
|Calories from fat||15|
|Total Fat||1.3 g|
|Saturated fat||0 g|
|Borage seed oil (Borago officinalis) supplying 299 mg gamma-linolenic acid (GLA)||1300 mg|
|Sesame seed (Sesamum indicum) lignan extract||10 mg|
|Other ingredients: gelatin, glycerin, purified water, silica, soy lecithin, rosemary, carob.|
|Contains soybeans. Contains sesame.
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster crab, shrimp), tree nuts, wheat, yeast, gluten, corn, or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.
Dosage and Use
Take one softgel one to two times daily with food, or as recommended by a healthcare practitioner.
Up to five softgels can be taken daily.
WARNINGS: Keep out of reach of children. Do not exceed recommended dose.